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Anti-Calnexin Antibody
Anti-Calnexin Antibody
- 中文名称：
- Anti-Calnexin Antibody
- 英文名称：
- Anti-Calnexin Antibody
- 品牌：
- Aves Labs
- 品牌介绍：
- Aves Labs自1995年以来一直引领着高度验证的鸡抗体开发行业，并提供以神经科学为重点的产品目录。鸡与哺乳动物在进化上有所不同，它们产生IgY抗体，可以更有选择性地靶向高度保守的哺乳动物蛋白质。鸡抗体也是当今非常热门的多重检测应用的首选。Aves Labs开创了寻找蛋白质中非常高免疫原性序列的新算法，并利用这一专业知识生产性能无与伦比的抗体。在位于加利福尼亚州戴维斯的ISO-13485认证设施中，不断开发新型抗体，并提供定制抗体服务。
- 货号：
- CANX-0020
- 规格：
- 100 µL
- 保存建议：
- Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.
- 背景资料：
- Calnexin is a vital chaperone protein involved in the quality control of glycoprotein folding within the endoplasmic reticulum (ER), facilitating correct folding and preventing aggregation. Calnexin’s calcium-dependent binding highlights its role in calcium homeostasis within the ER. The importance of calnexin extends beyond protein folding; it is crucial for immune function, as it assists in the assembly of major histocompatibility complex (MHC) class I molecules, thus playing a part in antigen presentation. Defects or dysregulation in calnexin prominently feature in cystic fibrosis (Pind et al. 1994), where misfolding of the CFTR glycoprotein is not efficiently managed by the calnexin cycle, leading to its degradation and resulting in disease. Due to its importance in protein folding and homeostasis, calnexin dysfunction can also lead to neurodegenerative disorders including Alzheimer’s, Parkinson’s, ALS, and Huntington’s. Dysregulation of these processes can also contribute to tumor development and progression, making calnexin a critical player in cancers including breast, prostate, liver, and lung. Recent studies have identified calnexin as a dual-role biomarker in lung cancer by utilizing anti-Calnexin antibodies for both diagnostic and therapeutic targeting (Lim et al. 2024).
- 货期：
- 4-6周
- 来源宿主：
- Chicken
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- ICC, IHC, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:200 µg/mL
推荐稀释比（WB）:1:2000-1:10000
推荐稀释比（IHC）:1:100-1:500
推荐稀释比（ICC）:1:100-1:500
- 说明书：
Our Anti-CANX (Calnexin) chicken polyclonal primary antibody from Aves Labs is produced in-house. It detects human, mouse, and rat CANX (Calnexin), and is affinity-purified IgY. It is great for use in IHC, ICC, WB.
