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Anti-Prion Protein Antibody
Anti-Prion Protein Antibody
- 中文名称：
- Anti-Prion Protein Antibody
- 英文名称：
- Anti-Prion Protein Antibody
- 品牌：
- Aves Labs
- 品牌介绍：
- Aves Labs自1995年以来一直引领着高度验证的鸡抗体开发行业，并提供以神经科学为重点的产品目录。鸡与哺乳动物在进化上有所不同，它们产生IgY抗体，可以更有选择性地靶向高度保守的哺乳动物蛋白质。鸡抗体也是当今非常热门的多重检测应用的首选。Aves Labs开创了寻找蛋白质中非常高免疫原性序列的新算法，并利用这一专业知识生产性能无与伦比的抗体。在位于加利福尼亚州戴维斯的ISO-13485认证设施中，不断开发新型抗体，并提供定制抗体服务。
- 货号：
- PRN
- 规格：
- 200 µL
- 保存建议：
- Store at -20°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile.
- 背景资料：
- Prion protein is a ubiquitously-expressed, 27661 dalton protein (253 amino acids, NP_898902.1) of unclear function(s) in eukaryotes. This protein can exist in one of two conformational forms. One is its normally-folded form (PrPc or "cellular PrP"), which contains a mixture of alpha helical regions and a few beta-pleated sheets. The other is a misfolded form (PrPsc or "scrapie PrP") whose structure contains mostly beta-pleated sheets. This misfolded scrapie PrP form is cytotoxic, especially to nervous tissue, and can serve as a "seed," inducing adjacent, normally-folded PrP proteins to misfold into the cytotoxic conformation. In this sense, the scrapie PrP can be thought of as an infectious agent both within the organism as well between organisms.
- 货期：
- 4-6周
- 来源宿主：
- Chicken
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- IHC, ICC, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:10 mg/mL
推荐稀释比（WB）:1:2500-1:5000
推荐稀释比（IHC）:1:1000-1:2000
推荐稀释比（ICC）:1:1000-1:2000
- 说明书：
Antibodies were prepared by injecting laying hens with purified recombinant human PRN protein. After a series of boosts, eggs were collected from hyperimmunized aniamsl and the IgY fraction prepared. Affinity purified antibodies were then isolated from the IgY fraction using a PRN protein column. Finally, affinity purified antibodies were mixed with the IgY fraction to make the final product. These antibodies have been validated with human, mouse and rat tissues.
