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Anti-M6PR (2G11) Recombinant Chicken Chimeric mAb FL490 Conjugate
Anti-M6PR (2G11) Recombinant Chicken Chimeric mAb FL490 Conjugate
- 中文名称：
- Anti-M6PR (2G11) Recombinant Chicken Chimeric mAb FL490 Conjugate
- 英文名称：
- Anti-M6PR (2G11) Recombinant Chicken Chimeric mAb FL490 Conjugate
- 品牌：
- Aves Labs
- 品牌介绍：
- Aves Labs自1995年以来一直引领着高度验证的鸡抗体开发行业，并提供以神经科学为重点的产品目录。鸡与哺乳动物在进化上有所不同，它们产生IgY抗体，可以更有选择性地靶向高度保守的哺乳动物蛋白质。鸡抗体也是当今非常热门的多重检测应用的首选。Aves Labs开创了寻找蛋白质中非常高免疫原性序列的新算法，并利用这一专业知识生产性能无与伦比的抗体。在位于加利福尼亚州戴维斯的ISO-13485认证设施中，不断开发新型抗体，并提供定制抗体服务。
- 货号：
- 78-603-FL490
- 规格：
- 200 µL
- 保存建议：
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
- 背景资料：
- The cation-independent mannose-6-phosphate receptor (CI-M6PR), also known as the insulin-like growth factor 2 receptor (IGF2R), is a large type I transmembrane glycoprotein of ~300 kDa that mediates trafficking of lysosomal hydrolases. CI-M6PR recognizes mannose-6-phosphate (M6P) tags on newly synthesized enzymes and facilitates their transport from the trans-Golgi network to endosomes, ensuring proper lysosomal function. In addition to its canonical role in lysosomal enzyme sorting, CI-M6PR regulates extracellular signaling by binding and internalizing insulin-like growth factor 2 (IGF2), thereby modulating cell growth and proliferation. Loss or dysregulation of CI-M6PR expression has been associated with impaired lysosomal biogenesis, altered growth factor signaling, and tumorigenesis, highlighting its dual role in both intracellular trafficking and growth regulation. Because of its involvement in cancer biology and lysosomal storage disorders, CI-M6PR is an important marker and functional regulator in both health and disease.
- 货期：
- 4-6周
- 来源宿主：
- Chicken
- 反应种属：
- Bovine, Human, and Non-Human Primate
- 应用：
- IHC, ICC
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:0.5 mg/mL
推荐稀释比（IHC）:1:100-1:500
推荐稀释比（ICC）:1:100-1:500
Our Anti-M6PR chicken recombinant primary antibody from Aves Labs is produced in-house from hybridoma clone 2G11. It detects human, monkey, and bovine M6PR, and is purified by affinity chromatography. It is great for use in IHC, ICC.
