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Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (ATTO 488)
Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (ATTO 488)
- 中文名称：
- Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (ATTO 488)
- 英文名称：
- Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (ATTO 488)
- 品牌：
- Biosensis
- 货号：
- M-026-50-AT
- 规格：
- 50 µg
- 保存建议：
- The antibody conjugate can be stored at 2-8°C for up to 4 months with the addition of appropriate antibacterial agent.
- 背景资料：
- Monoclonal antibody MC192 against the rat low affinity nerve growth factor receptor (p75NTR) is derived from the fusion of Sp2/0-Ag 14 myeloma cells with mouse immune splenocytes. MC192 monoclonal antibody was originally generated by Chandlers et al. p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (By similarity).
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 应用：
- FC, ICC, IHC-Frozen, IHC-Paraffin-embedded
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-NGFR/p75 neurotrophin receptor (p75NTR) mouse monoclonal primary antibody detects rat NGFR/p75 neurotrophin receptor (p75NTR), and is igg. It is validated for use in FC, ICC, IHC-Frozen, IHC-Paraffin-embedded.
