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Anti-Integrin beta 2 alpha subunit (CD11b/c, Mac-1) Antibody
Anti-Integrin beta 2 alpha subunit (CD11b/c, Mac-1) Antibody
- 中文名称：
- Anti-Integrin beta 2 alpha subunit (CD11b/c, Mac-1) Antibody
- 英文名称：
- Anti-Integrin beta 2 alpha subunit (CD11b/c, Mac-1) Antibody
- 品牌：
- Biosensis
- 货号：
- M-1325-100
- 规格：
- 100 µg
- 保存建议：
- Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material. Final solution will contain no preservatives12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- 背景资料：
- Clone OX-42 recognizes the rat equivalent of human CD11b and shares a common epitope with CB11c (integrin apha M and alpha X chains). (PMID:1672643; Tamatani T et al 1991). CD11b is a single-pass type I membrane protein that belongs to the integrin alpha chain family. CD11b is predominantly expressed in monocytes and granulocytes and is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles (Ref: SWISSPROT). CD11b is also frequently used as a microglial marker allowing to distinguish between quiescent and activated microglia based on the intensity of CD11b staining. Moreover the OX-42 monoclonal antibody specifically binds to the CR3 complement (C3bi) receptor found on most monocytes, granulocytes, macrophages, dendritic cells, and microglia. OX-42 antibody inhibits C3bi binding activity.
CD11b, also known as integrin alpha M or Mac-1, and is a component of complement receptor 3 (CR3). CD11c, also known as integrin alpha X, and is a component of complement receptor 4 (CR4). Integrin alpha-X/beta-2 is a receptor for fibrinogen. CD11b and CD11c are expressed on immune cells such as macrophages, monocytes, granulocytes, and dendritic cells. OX42 has also been shown to detect microglia in the brain, as well as cells of the liver and epidermis.
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 应用：
- FC, ICC, IHC-Paraffin-embedded, IP
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-Integrin beta 2 alpha subunit mouse monoclonal primary antibody detects rat Integrin beta 2 alpha subunit , and is igg. It is validated for use in FC, ICC, IHC-Paraffin-embedded, IP.
