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Anti-High-Mobility Group Protein 1 (HMGB1) Antibody
Anti-High-Mobility Group Protein 1 (HMGB1) Antibody
- 中文名称：
- Anti-High-Mobility Group Protein 1 (HMGB1) Antibody
- 英文名称：
- Anti-High-Mobility Group Protein 1 (HMGB1) Antibody
- 品牌：
- Biosensis
- 货号：
- M-1702-100
- 规格：
- 100 µg
- 保存建议：
- Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. After reconstitution of lyophilized antibody, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- 背景资料：
- High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 应用：
- FC, ICC, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-High-mobility group protein 1 (HMGP-1) mouse monoclonal primary antibody detects bovine, human, mouse, other mammals (predicted), pig, and rat High-mobility group protein 1 (HMGP-1), and is igg. It is validated for use in FC, ICC, WB.
