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Anti-Tyrosine Kinase Receptor A (TrkA) Antibody
Anti-Tyrosine Kinase Receptor A (TrkA) Antibody
- 中文名称：
- Anti-Tyrosine Kinase Receptor A (TrkA) Antibody
- 英文名称：
- Anti-Tyrosine Kinase Receptor A (TrkA) Antibody
- 品牌：
- Biosensis
- 货号：
- R-152-100
- 规格：
- 100 µL
- 保存建议：
- Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- 背景资料：
- TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer.
- 货期：
- 4-6周
- 来源宿主：
- Rabbit
- 应用：
- ELISA, IHC-Frozen
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-Tyrosine Kinase Receptor A (TrkA) rabbit polyclonal primary antibody detects human, mouse, and rat Tyrosine Kinase Receptor A (TrkA), and is whole serum. It is validated for use in ELISA, IHC-Frozen.
