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Anti-LRRK2 Antibody
Anti-LRRK2 Antibody
- 中文名称：
- Anti-LRRK2 Antibody
- 英文名称：
- Anti-LRRK2 Antibody
- 品牌：
- Biosensis
- 货号：
- R-183-50
- 规格：
- 50 µg
- 保存建议：
- Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water and centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- 背景资料：
- LRRK2 is a member of the leucine-rich repeat kinase family. Its role is yet unknown but it may play a role in the phoshorylation of proteins central to parkinson diseases. LRRK2 contains an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a mLK-like domain and a WD40 domain. LRRK2 is present in the cytoplasm but also associates with the mitochondrial outer membrane. Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8). Parkinson disease is characterised by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late-onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.
- 货期：
- 4-6周
- 来源宿主：
- Rabbit
- 应用：
- IHC-Frozen
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) rabbit polyclonal primary antibody detects human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), and is affinity purified. It is validated for use in IHC-Frozen.
