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Anti-Alpha-synuclein Antibody
Anti-Alpha-synuclein Antibody
- 中文名称：
- Anti-Alpha-synuclein Antibody
- 英文名称：
- Anti-Alpha-synuclein Antibody
- 品牌：
- Biosensis
- 货号：
- S-075-50
- 规格：
- 50 µg
- 保存建议：
- Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- 背景资料：
- Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
- 货期：
- 4-6周
- 来源宿主：
- Sheep
- 应用：
- ELISA, IHC-Frozen, IHC-Paraffin-embedded, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-Alpha-synuclein sheep polyclonal primary antibody detects human, mouse, and rat Alpha-synuclein , and is affinity-purified. It is validated for use in ELISA, IHC-Frozen, IHC-Paraffin-embedded, WB.
