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Rabbit anti Human ERCC1 (DNA excision repair protein)
Rabbit anti Human ERCC1 (DNA excision repair protein)
- 中文名称：
- Rabbit anti Human ERCC1 (DNA excision repair protein)
- 英文名称：
- Rabbit anti Human ERCC1 (DNA excision repair protein)
- 品牌：
- Nordic-MUbio
- 品牌介绍：
- Nordic公司成立于1964年，是荷兰著名免疫学试剂生产厂商，拥有超过1700种针对人、小鼠、猴和大鼠的免疫球蛋白及其亚型的特异性抗血清。公司主要产品包括一系列广泛的针对不同物种血清蛋白的多克隆抗血清，以及针对酶的一系列独特的多克隆抗血清。
- 货号：
- X2734P
- 规格：
- 100 µg
- 保存建议：
- -20ºC. Aliquot to avoid freeze/thaw cycles
- 背景资料：
- Recognizes a protein of 33-36kDa, identified as the Excision Repair Cross Complementing (ERCC1). The mammalian ERCC1-encoded polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The structure-specific ERCC1/XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV-induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross-links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.
- 货期：
- 现货/4周
- 来源宿主：
- Rabbit
- 应用：
- Western Blotting|Immunohistochemistry (paraffin)|Western Blotting|Immunohistochemistry (paraffin)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
别名 / 同义词:Excision Repair Cross Complementing protein-1; Nucleotide Excision Repair Protein
克隆号/Clone:N/A
亚型/Isotype:Ig
研究领域/Field of Interest:Signal Transduction
标记/Label:N/A
- 说明书：
