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Rabbit anti Human PH Domain-containing family E member 1
Rabbit anti Human PH Domain-containing family E member 1
- 中文名称：
- Rabbit anti Human PH Domain-containing family E member 1
- 英文名称：
- Rabbit anti Human PH Domain-containing family E member 1
- 品牌：
- Nordic-MUbio
- 品牌介绍：
- Nordic公司成立于1964年，是荷兰著名免疫学试剂生产厂商，拥有超过1700种针对人、小鼠、猴和大鼠的免疫球蛋白及其亚型的特异性抗血清。公司主要产品包括一系列广泛的针对不同物种血清蛋白的多克隆抗血清，以及针对酶的一系列独特的多克隆抗血清。
- 货号：
- X2736P
- 规格：
- 100 µg
- 保存建议：
- -20ºC. Aliquot to avoid freeze/thaw cycles
- 背景资料：
- PHLPP1 is a 1717 aa protein with phosphatase activity that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.
- 货期：
- 现货/4周
- 来源宿主：
- Rabbit
- 应用：
- Western Blotting|Immunohistochemistry|Western Blotting|ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
别名 / 同义词:KIAA0606, PHLPP, PLEKHE1, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein
克隆号/Clone:N/A
亚型/Isotype:Ig
研究领域/Field of Interest:N/A
标记/Label:N/A
- 说明书：
