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LIN28 (EP150)
LIN28 (EP150)
- 中文名称：
- LIN28 (EP150)
- 英文名称：
- LIN28 (EP150)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59340
- 规格：
- 5 Slides|2x5 Slides|3x5 Slides|4x5 Slides|
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[EP150]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
LIN28 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
LIN28 homolog A is a protein that in humans is encoded by the LIN28 gene. LIN28 is thought to regulate the self-renewal of stem cells, is highly expressed in human embryonic stem cells and can enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts.
LIN28 antibody has been found to be a highly sensitive marker for testicular intratubular germ cell neoplasias, classic seminomas, embryonal carcinomas, and yolk sac tumors (YST) with relatively high specificity. LIN28 can be used as a test marker for these tumors and has demonstrated a similar level of test utility as SALL4. The major advantage of LIN28 over OCT4 is in identifying yolk sac tumors (yolk sac tumors negative for OCT4). In another study, LIN28 antibody was found to be a sensitive marker of ovarian primitive germ cell tumors like Gonadoblastomas, Dysgerminomas, Embryonal Carcinomas, and YSTs. LIN28 can be used to distinguish them from non- testicular germ cell tumors. High expression of Lin28 is associated with poor prognosis and high tumor aggressiveness in esophageal cancer and these effects are mediated through increased proliferation and invasiveness of esophageal cancer cells.
