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Recombinant Human KRAS Protein
Recombinant Human KRAS Protein
- 中文名称：
- Recombinant Human KRAS Protein
- 英文名称：
- Recombinant Human KRAS Protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA55968
- 规格：
- 0.1 mg|0.5 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Store it under sterile condition s at-20°C upon receiving. Recommend to aliquot theprotein into smaller quantities for optimal storage.**Avoid repeated freeze-thaw cycles.**
Stability: The recombinant protein is stable for up to 6 months from date of receipt at -80°C
- 货期：
- 6-8周
- CAS号：
- 559-68-2
- 纯度：
- > 85% as determined by SDS-PAGE.
- 属性（合成/天然）：
- 天然
- 产品形式：
- Lyophilized ; 58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, pH 7.4 added with 300 mM Imidazole and 15% glycerol.
- 分子量：
- 456.70 g/mol
- 分子式：
- C30H48O3
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Like other members of the Ras family, the KRAS protein is a GTPase and is an early player in many signal transduction pathways. KRAS is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. When mutated, KRAS is a oncogene. The protein product of the normal KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers. KRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation of growth factor and other receptors signal, such as c-Raf and PI 3-kinase. KRAS binds to GTP in the active state and possesses an intrinsic enzymatic activity which cleaves the terminal phosphate of the nucleotide converting it to GDP.
