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INI-1 (RBT-INI1)
INI-1 (RBT-INI1)
- 中文名称：
- INI-1 (RBT-INI1)
- 英文名称：
- INI-1 (RBT-INI1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59416
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RBT-INI1]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
INI-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is involved in chromatin remodeling and transcriptional regulation and also known as hSNF5, SMARCB1 and BAF47.
INI-1 is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential identification. The overall survival of MRTs relative to its potential mimics such as medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by INI-1 antibody. MRTs also originate from the kidney and soft tissues. Germline INI-1 mutations are associated with sporadic schwannomatosis and rhabdoid tumors. INI-1 antibody has been used to distinguish atypical teratoid/rhabdoid tumor (loss of INI1) from choroid plexus carcinoma (positive for INI-1) and to differentiate epithelioid sarcoma (loss of INI1) from epithelioid hemangioendothelioma (positive for INI-1).
