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BiP/GRP78 Antibody
BiP/GRP78 Antibody
- 中文名称：
- BiP/GRP78 Antibody
- 英文名称：
- BiP/GRP78 Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA111271
- 规格：
- 0.1 mg|0.1 mL (AF647)|0.1 mL (AF594)|0.1 mL (HRP)|0.1 mL (PE)
- 保存建议：
- 请按照说明书指示
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Rat
- 应用：
- ICC (Immunocytochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:N/A
特异性:This antibody detects endogenous levels BiP/GRP78 and does not cross-react with related proteins.
纯度:Affinity purified
形式：Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
浓度：N/A
- 说明书：
UniPort Summary Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER
Entrez Summary: The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
