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Anti-NIPP1/Ppp1r8 Antibody, Rabbit Polyclonal
Anti-NIPP1/Ppp1r8 Antibody, Rabbit Polyclonal
- 中文名称：
- Anti-NIPP1/Ppp1r8 Antibody, Rabbit Polyclonal
- 英文名称：
- Anti-NIPP1/Ppp1r8 Antibody, Rabbit Polyclonal
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259398
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- This antibody can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- IP (Immunoprecipitation), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Rabbit IgG
克隆号:N/A
特异性:Human
Mouse (Species predicted to react based on 100% sequence homology)
纯度:Protein A & Antigen Affinity
形式：Liquid; 0.2um filtered solution in PBS
浓度：N/A
- 说明书：
The ubiquitously expressed nuclear protein NIPP1 (also known as PPP1R8) recruits phosphoproteins for regulated dephosphorylation by the associated protein phosphatase PP1. The deletion of NIPP1 in mice is early embryonic lethal, which has precluded functional studies in adult tissues. Nuclear Inhibitor of PP1 (NIPP1; 351 residues in mouse), encoded by Ppp1r8, is one of the major nuclear interactors of PP1 and is expressed in nearly all eukaryotic cells. The N-terminal third of NIPP1 largely consists of a well-structured ForkHead-Associated (FHA) domain, while the remainder of the protein is intrinsically disordered but becomes partially structured upon binding to PP1. The FHA domain of NIPP1 mediates the recruitment of a subset of phosphoproteins, including the pre-mRNA splicing factors SAP155 and CDC5L, protein kinase MELK and the methyltransferase EZH2, for regulated dephosphorylation by associated PP1.
