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Anti-SON Antibody, Rabbit Polyclonal
Anti-SON Antibody, Rabbit Polyclonal
- 中文名称：
- Anti-SON Antibody, Rabbit Polyclonal
- 英文名称：
- Anti-SON Antibody, Rabbit Polyclonal
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259455
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- This antibody can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- IHC (Immunohistochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Rabbit IgG
克隆号:N/A
特异性:Human SON
纯度:Protein A & Antigen Affinity
形式：Liquid; PBS, pH7.0 with 0.03% Proclin300
浓度：N/A
- 说明书：
SON is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. SON involves in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. SON is a key component of the spliceosomal complex and a critical mediator of constitutive and alternative splicing. During constitutive RNA splicing, SON ensures efficient intron removal from the transcripts containing suboptimal splice sites. Importantly, SON-mediated splicing is required for proper processing of selective transcripts related to cell cycle, microtubules, centrosome maintenance, and genome stability. Moreover, SON regulates alternative splicing of RNAs from the genes involved in apoptosis and epigenetic modification. In addition to the role in RNA splicing, SON has the ability to suppress transcriptional activation at certain promoter/enhancer DNA sequences. Deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies. SON plays important roles in nuclear organization and pre-mRNA splicing as well as maintaining cellular health. SON has a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis.
