-
CHOP Polyclonal Antibody
CHOP Polyclonal Antibody
- 中文名称：
- CHOP Polyclonal Antibody
- 英文名称：
- CHOP Polyclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA266911
- 规格：
- 0.1 mL|0.1 mL (AF647)|0.1 mL (AF594)|0.1 mL (HRP)|0.1 mL (PE)
- 保存建议：
- Store at -20 degree C or -80 degree C. Avoid freeze/thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Affinity purification
形式：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
浓度：N/A
- 说明书：
CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner (1). CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lalpha expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2alpha thereby stimulating protein synthesis. Ero1-Lalpha promotes oxidative stress inside the endoplasmic reticulum (ER) (4). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER (4).
