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Rev-erbalpha Antibody
Rev-erbalpha Antibody
- 中文名称：
- Rev-erbalpha Antibody
- 英文名称：
- Rev-erbalpha Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA267173
- 规格：
- 0.1 mL|0.1 mL (AF647)|0.1 mL (AF594)|0.1 mL (HRP)|0.1 mL (Cy7)
- 保存建议：
- Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Affinity purification
形式：N/A
浓度：N/A
- 说明书：
Reverse orientation c-erbA gene alpha (Rev-erbalpha, EAR-1, or NR1D1) is a widely expressed member of the orphan nuclear receptor family of proteins (1). Rev-erbalpha is highly expressed in adipose tissue, skeletal muscle, brain and liver, and regulates cellular proliferation and differentiation. Expression increases during differentiation in adipocytes and ectopic expression of Rev-erbalpha potentiates the adipocyte differentiation of 3T3-L1 cells (2). In addition, expression oscillates with circadian rhythm in liver cells and Rev-erbalpha regulates expression of BMAL1, ApoA-I and ApoC-III, all key regulators of circadian rhythm (3, 4, 5, 6, 7). Phosphorylation of Rev-erbalpha Ser55 and Ser59 by GSK3beta appears to stabilize Rev-erbalpha protein levels and is important for synchronizing and maintaining the circadian clock (8). Rev-erbalpha also regulates inflammation by targeting the NF-kappaB responsive genes IL-6 and COX-2 (9). Rev-erbalpha lacks the activation function 2 domain required for ligand-dependent activation of transcription by other members of the nuclear receptor family; thus it behaves as a constitutive repressor protein, recruiting the nuclear receptor co-repressor (N-CoR)/HDAC3 complex to target genes to repress transcription (10).
