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Phospho-PI3-kinase p85-alpha (Tyr607) Antibody
Phospho-PI3-kinase p85-alpha (Tyr607) Antibody
- 中文名称：
- Phospho-PI3-kinase p85-alpha (Tyr607) Antibody
- 英文名称：
- Phospho-PI3-kinase p85-alpha (Tyr607) Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA267877
- 规格：
- 0.05 mg|0.1 mg|0.1 mL (AF405S)|0.1 mL (AF405L)|0.1 mL (AF546)
- 保存建议：
- Store at -20°C for 1 year
- 货期：
- 6-8周
- 来源宿主：
- N/A
- 反应种属：
- Human, Mouse, Rat
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:Rabbit IgG
克隆号:N/A
特异性:Phospho-PI3-kinase p85-alpha (Tyr607) Antibody detects endogenous levels of PI3-kinase p85-alpha only when phosphorylated at Tyrosine 607
纯度:Immunogen affinity purified
形式：In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度：N/A
- 说明书：
PIK3R1 is a regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.
