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Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin)
Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin)
- 中文名称：
- Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin)
- 英文名称：
- Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA26910
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Bovine, Human, Monkey, Mouse, Porcine, Rat
- 应用：
- FCM/FACS (Flow Cytometry), IC (Immunochemistry), IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[10g129(13E5)]
特异性:Recognizes endogenous levels of total human beta-actin protein at ~45kD. May crossreact with the gamma-actin (cytoplasmic isoform). Does not crossreact with alpha-skeletal, alpha-cardiac, alpha-vascular smooth or gamma-enteric smooth muscle isoforms. Species Crossreactivity: mouse, rat, monkey, bovine, porcine.
纯度:Purified
形式：Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.
浓度：N/A
- 说明书：
Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle b- and g-actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility (1). a-cardiac anda-skeletal actin are expressed in striated cardiac and skeletal muscles, respectively; two smooth muscle actins, a- and g-actin, are found primarily in vascular smooth muscle and enteric smooth muscle, respectively. These actin isoforms regulate the contractile potential of muscle cells (1). Actin exists mainly as a fibrous polymer, F-actin. In response to cytoskeletal reorganizing signals during processes such as cytokinesis, endocytosis, or stress, cofilin promotes fragmentation and depolymerization of F-actin, resulting in an increase in the monomeric globular form, G-actin (2). The Arp2/3 complex stabilizes F-actin fragments and promotes formation of new actin filaments (2). It has been reported that actin is hyperphosphorylated in primary breast tumors (3). Cleavage of actin under apoptotic conditions has been observed in vitro and in cardiac and skeletal muscle (4-6). Actin cleavage by caspase-3 may accelerate ubiquitin/proteosome dependent muscle proteolysis (6).
