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Phospho-SMAD2 (S118) Antibody
Phospho-SMAD2 (S118) Antibody
- 中文名称：
- Phospho-SMAD2 (S118) Antibody
- 英文名称：
- Phospho-SMAD2 (S118) Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA288611
- 规格：
- 0.08 mL|0.4 mL|2x0.4 mL|3x0.4 mL|4x0.4 mL
- 保存建议：
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human (Predicted Reactivity: Drosophila, Bovine, Zebrafish, Mouse, Rat, Chicken, Pig)
- 应用：
- ELISA, DB (Dot Blot), IF (Immunofluorescence)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Rabbit IgG
克隆号:N/A
特异性:This SMAD2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S118 of human SMAD2.
纯度:This antibody is purified through a protein A column, followed by peptide affinity purification.
形式：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
浓度：N/A
- 说明书：
The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
