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IKK-gamma (Phospho-Ser85) Antibody
IKK-gamma (Phospho-Ser85) Antibody
- 中文名称：
- IKK-gamma (Phospho-Ser85) Antibody
- 英文名称：
- IKK-gamma (Phospho-Ser85) Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA306559
- 规格：
- 0.05 mL|0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL
- 保存建议：
- 储存在-20摄氏度/1年
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse
- 应用：
- WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:N/A
克隆号:N/A
特异性:The antibody detects endogenous level of IKK-y only when phosphorylated at serine 85.
纯度:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
形式：Liquid in PBS containing 50%glycerol, 0.5% BSA and 0.02% sodium azide.
浓度：1.0 mg/ml
- 说明书：
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Niu J, Shi Y, Iwai K, Wu ZH (2011) EMBO J 30, 3741-53.
Wu ZH, et al. (2010)Mol Cell 40, 75-86.
Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB (2008)J Biol Chem 283, 76-86.
