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IL1A Antibody
IL1A Antibody
- 中文名称：
- IL1A Antibody
- 英文名称：
- IL1A Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA307104
- 规格：
- 0.05 mL|0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL
- 保存建议：
- 储存在-20摄氏度
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:N/A
克隆号:N/A
特异性:The antibody detects endogenous level of total IL1A protein.
纯度:Antibodies were purified by affinity purification using immunogen.
形式：Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度：1.0 mg/ml
- 说明书：
IL-1a is a pro-inflammatory cytokine produced by activated monocytes, lymphocytes and epithelial cells (1). IL-1a is synthesized as an active precursor protein that appears to be cleaved by cytosolic proteases into its mature form (1,2). Often, precursor and mature forms of IL-1a are primarily retained intracellularly rather than constitutively secreted. (1,2). Signaling by IL-1a involves IL-1a binding to an IL-1 accessory protein (IL-1-AcP) and then the complex binds to IL-1RI (1,2). Signaling is through activation of MAP kinase and NFkB pathways (1,2). IL-1a also binds to an IL-RII that lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. Inhibition of IL-1a activity is through IL-1R antagonist (IL-1Ra) that binds IL-1R1 but does not signal. IL-1a has been shown to be a key mediator of virus-induced inflammatory responses in mice (3).
