-
TESC Antibody
TESC Antibody
- 中文名称：
- TESC Antibody
- 英文名称：
- TESC Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA308564
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- 储存在-20摄氏度
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- IHC (Immunohistochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:N/A
克隆号:N/A
特异性:The antibody detects endogenous levels of total TESC protein.
纯度:Antigen Affinity Purification
形式：Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
浓度：1.1 mg/ml
- 说明书：
Tescalcin, also known as TESC, TSC or CHP3, is a 267 amino acid protein that contains one EF-hand domain and is expressed abundantly in adult heart tissue. Using calcium as a cofactor, Tescalcin interacts with NHE-1 and functions to couple the activation of the ERK cascade with the expression of Ets proteins during megakaryocytic differentiation.Human Tescalcin shares 97% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoformsof Tescalcin exist due to alternative splicing events. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity.Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
