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Pyruvate Dehydrogenase E2 Mouse mAb
Pyruvate Dehydrogenase E2 Mouse mAb
- 中文名称：
- Pyruvate Dehydrogenase E2 Mouse mAb
- 英文名称：
- Pyruvate Dehydrogenase E2 Mouse mAb
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA320350
- 规格：
- 0.04 mL|0.1 mL|0.2 mL|2x0.2 mL|3x0.2 mL
- 保存建议：
- 储存在-20摄氏度/1年
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse
- 应用：
- IP (Immunoprecipitation), ICC (Immunocytochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:N/A
克隆号:N/A
特异性:This antibody detects endogenous levels of Pyruvate Dehydrogenase E2 and does not cross-react with related proteins.
纯度:The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
形式：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
浓度：1mg/ml
- 说明书：
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lact
