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ITPK1 Antibody
ITPK1 Antibody
- 中文名称：
- ITPK1 Antibody
- 英文名称：
- ITPK1 Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA321123
- 规格：
- 0.1 mL|0.2 mL|2x0.2 mL|3x0.2 mL|4x0.2 mL
- 保存建议：
- 收到后，可在-20摄氏度储存12个月。
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse
- 应用：
- ELISA, ICC (Immunocytochemistry), IF (Immunofluorescence), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:ITPK1 antibody detects endogenous levels of ITPK1
纯度:The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
形式：Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度：1mg/ml
- 说明书：
Description: ITPK1 Kinase that can phosphorylate various inositol polyphosphate such as Ins(3, 4, 5, 6)P4 or Ins(1, 3, 4)P3. Phosphorylates Ins(3, 4, 5, 6)P4 at position 1 to form Ins(1, 3, 4, 5, 6)P5. This reaction is thought to have regulatory importance, since Ins(3, 4, 5, 6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1, 3, 4, 5, 6)P5 is not. Also phosphorylates Ins(1, 3, 4)P3 on O-5 and O-6 to form Ins(1, 3, 4, 6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 to Ins(1, 3, 4)P3, and Ins(1, 3, 4, 5, 6)P5 to Ins(3, 4, 5, 6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 in the presence of ADP and magnesium.
Function: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3, 4, 5, 6)P4 or Ins(1, 3, 4)P3. Phosphorylates Ins(3, 4, 5, 6)P4 at position 1 to form Ins(1, 3, 4, 5, 6)P5. This reaction is thought to have regulatory importance, since Ins(3, 4, 5, 6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl-channels, while Ins(1, 3, 4, 5, 6)P5 is not. Also phosphorylates Ins(1, 3, 4)P3 on O-5 and O-6 to form Ins(1, 3, 4, 6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 to Ins(1, 3, 4)P3, and Ins(1, 3, 4, 5, 6)P5 to Ins(3, 4, 5, 6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Subunit Structure: Monomer. Interacts with GPS1/COPS1.
Post-translational Modifications: Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1.
Similarity: Belongs to the ITPK1 family.
