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TRIM14 Antibody
TRIM14 Antibody
- 中文名称：
- TRIM14 Antibody
- 英文名称：
- TRIM14 Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA323313
- 规格：
- 0.1 mL|0.2 mL|2x0.2 mL|3x0.2 mL|4x0.2 mL
- 保存建议：
- 收到后，可在-20摄氏度储存12个月。
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:TRIM14 antibody detects endogenous levels of TRIM14.
纯度:The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
形式：Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度：1mg/ml
- 说明书：
Function: Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593).
Subunit Structure: Interacts with MAVS (PubMed:24379373). Interacts with WRNIP1 and PPP6C; these interactions positively regulate the RIG-I/DDX58 signaling pathway (PubMed:29053956). Interacts with CGAS; this interaction stabilizes CGAS and promotes type I interferon production (PubMed:27666593). Interacts with USP14; this interaction mediates the cleavage of 'Lys-48'-linked ubiquitination of CGAS (PubMed:27666593). Interacts with SPI1 (By similarity).
Post-translational Modifications: Ubiquitinated (PubMed:24379373). Undergoes 'Lys-63'-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS.
Similarity: The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation. Belongs to the TRIM/RBCC family.
