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Mouse monoclonal antibody Anti-Human CBFA2T2
Mouse monoclonal antibody Anti-Human CBFA2T2
- 中文名称：
- Mouse monoclonal antibody Anti-Human CBFA2T2
- 英文名称：
- Mouse monoclonal antibody Anti-Human CBFA2T2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA36317
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- 请按照说明书指示
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- FCM/FACS (Flow Cytometry), WB (Western Blot), ICC (Immunocytochemistry), DB (Dot Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[CBF5I134]
特异性:N/A
纯度:N/A
形式：N/A
浓度：100 ug/ml (1.0 ml)
- 说明书：
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [NCBI Entrez Gene Summary]
