-
Anti-CD33 antibody (DM77), Rabbit mAb
Anti-CD33 antibody (DM77), Rabbit mAb
- 中文名称：
- Anti-CD33 antibody (DM77), Rabbit mAb
- 英文名称：
- Anti-CD33 antibody (DM77), Rabbit mAb
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47309
- 规格：
- 0.01 mg|0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store at -20 degree C for 12 months (Avoid repeated freezing and thawing)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- FCM/FACS (Flow Cytometry), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Rabbit IgG
克隆号:[DM77]
特异性:N/A
纯度:Purified from cell culture supernatant by affinity chromatography
形式：Liquid. 50% Glycerol; PBS, pH7.4; 0.1% BSA; 0.1% Procline 300
浓度：N/A
- 说明书：
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2, 3- and more avidly alpha-2, 6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
