Prekallikrein Heavy Chain Monoclonal Antibody-Prekallikrein Heavy Chain Monoclonal Antibody-一抗检测抗体

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: Prekallikrein Heavy Chain Monoclonal Antibody

Prekallikrein Heavy Chain Monoclonal Antibody

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中文名称：: Prekallikrein Heavy Chain Monoclonal Antibody

英文名称：: Prekallikrein Heavy Chain Monoclonal Antibody

品牌：: AAA Biotech

品牌介绍：: AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。

货号：: AAA47712

规格：: 0.2 mg|2x0.2 mg|3x0.2 mg|4x0.2 mg|5x0.2 mg

保存建议：: This antibody is stable for at least one (1) year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

货期：: 6-8周

来源宿主：: Mouse

反应种属：: N/A

应用：: IB (Immunoblot), ELISA

免责声明：: *本产品仅供科研实验使用，不得用于临床诊断。*

其他：: 克隆性:Monoclonal
同型:IgG1
克隆号:[13G11]
特异性:Anti-Prekallikrein Heavy Chain [MurineMAb recognizes the heavy chain of human prekallikrein.]
This antibody specifically recognizes in human plasma two variants (88 kDa and 85 kDa) of prekallikrein and its activation products kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80% and 55%,respectively. This antibody does not cross-react with tissue kallikrein.
纯度:Purified human prekallikrein.
形式：Protein G-purified antibody in PBS, pH 7.4.
浓度：1.5mg/mL

说明书：

Background: Human prekallikrein, a serine protease zymogen, is present in plasma as two variants, 88kDa and 85kDa, probably due to different carbohydrate content. Approximately 75% of the total prekallikrein in plasma is noncovalently associated with high molecular weight kininogen (HMWK). HMWK mediates binding of prekallikrein to a negatively-charged surface which is required for its optimal activation to kallikrein by activated factor XII. Although kallikrein light and heavy chains can behave as functionally independent domains, the interaction between these two chains is essential for full biologic activity.

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