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Anti-LAMP2 Monoclonal Antibody
Anti-LAMP2 Monoclonal Antibody
- 中文名称：
- Anti-LAMP2 Monoclonal Antibody
- 英文名称：
- Anti-LAMP2 Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47740
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at -20°C. Avoid repeated freezing and thawing.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- N/A
- 应用：
- IB (Immunoblot), IF (Immunofluorescence)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:N/A
特异性:This antibody recognizes human, mouse, and rabbit LAMP2 (~100-110 kDa).
纯度:Purified by Protein G affinity chromatography
形式：Clear Liquid; 100ug in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. Preservative: 50% glycerol, 0.09% NaN3
浓度：N/A
- 说明书：
Lysosome-associated membrane proteins (LAMP1 and LAMP2) are major constituents of the lysosomal membrane. These two proteins have closely related structures with 37% sequence homology. Both are transmembrane glycoproteins localized primarily in lysosomes and late endosomes. LAMP2 has also been detected at the plasma membrane of cells undergoing differentiation and activation and in cells that secrete lysosomal hydrolases. In addition, it has been suggested that LAMP2 is involved in cell-cell or cell-extracellular matrix interactions. Cell surface LAMP1 and LAMP2 promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium which suggests that the LAMP proteins are involved in adhesion of PBMC to sites of inflammation. Studies with LAMP2-deficient mice indicate that involvement of LAMP2 is critical in the conversion of early autophagic vacuoles to vacuoles which rapidly degrade their contents. Defects in LAMP2 are associated with Danon disease.
