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Anti-AF4 Monoclonal Antibody
Anti-AF4 Monoclonal Antibody
- 中文名称：
- Anti-AF4 Monoclonal Antibody
- 英文名称：
- Anti-AF4 Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47760
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- N/A
- 应用：
- WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[C2.1.1]
特异性:This antibody recognizes human AF4.
纯度:Purified by Protein G
形式：Clear Liquid
浓度：1.1 mg/ml in PBS, pH 7.4
- 说明书：
The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. AF4 (also known as FEL) is a gene which was first described as a fusion partner with MLL in the t(4;11) acute leukemia. Based on analysis by Northern blotting, AF4 mRNAs were found to be widely expressed in hematopoietic cells and normal human tissues. cDNA sequence analysis of the AF4 gene showed that it encodes a serine/proline-rich protein with a predicted size of 130-140kDa containing guanosine triphosphate (GTP)-binding and putative nuclear-localization sequences. Studies have demonstrated that a related gene, LAF4, isolated from Burkitts lymphoma, shares high degree of sequence homology with AF4. LAF4 was shown to possess DNA binding ability and transcriptional activation potential. Both AF4 and LAF4 were shown to be evolutionary conserved in vertebrates suggesting an important functional role of the genes.
