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MOUSE ANTI HUMAN SIGLEC-10
MOUSE ANTI HUMAN SIGLEC-10
- 中文名称：
- MOUSE ANTI HUMAN SIGLEC-10
- 英文名称：
- MOUSE ANTI HUMAN SIGLEC-10
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA50148
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at +4°C or at -20°C if prefered.
Storage in forst-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 货期：
- 6-8周
- 来源宿主：
- N/A
- 反应种属：
- N/A
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[5G6]
特异性:SIGLEC-10
Mouse anti Human Siglec-10 antibody, clone 5G6 recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and membrane of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preerentially binds to glycoconjugates containing alpha-2,3- or alpha -2,6- linked sialic acid. Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on edothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Mouse anti Human Siglec-10 antibody, clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9.
纯度:N/A
形式：Purified IgG - liquid; PBS
浓度：IgG concentration 1.0 mg/ml
- 说明书：
Clone 5G6 specifically recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see Kive, E. et al. for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see Munday J. et al. for details.
