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RAT ANTI MOUSE TIM-1:RPE
RAT ANTI MOUSE TIM-1:RPE
- 中文名称：
- RAT ANTI MOUSE TIM-1:RPE
- 英文名称：
- RAT ANTI MOUSE TIM-1:RPE
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA50172
- 规格：
- 100 Tests|2x100 Tests|3x100 Tests|4x100 Tests|5x100 Tests
- 保存建议：
- Prior to reconstitution store at 4 degree C. After reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- N/A
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[RMT1-10]
特异性:N/A
纯度:N/A
形式：Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised.
浓度：N/A
- 说明书：
Rat anti Mouse TIM-1 antibody, clone MBS239187-10 recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Rat anti Mouse TIM-1 antibody, clone MBS239187-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies (Xiao et al. 2007). Rat anti Mouse TIM-1 antibody, clone MBS239187-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies (Xiao et al. 2007).
