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Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8
Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8
- 中文名称：
- Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8
- 英文名称：
- Mouse Anti-Human CD106 Monoclonal Antibody, Azide Free Clone B-N8
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA58565
- 规格：
- 0.2 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- 1 year: 2-8°C
Long Term: (Aliquot) -20°C.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG1 Kappa light chain
克隆号:[B-N8]
特异性:Recognises the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein
纯度:Ion exchange chromatography
形式：Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
浓度：N/A
- 说明书：
BACKGROUND:The vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or differentiation group 106 (CD106), is a protein that in humans is coded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.
The VCAM-1 protein induces the adhesion of lymphocytes, monocytes, eosinophils and basophils to the vascular endothelium. It also plays a role in signal transduction of leukocyte-endothelial cells and may play a role in the development of atherosclerosis and rheumatoid arthritis.
Positive regulation of VCAM-1 in endothelial cells by cytokines results from increased transcription of the gene (eg, in response to tumor necrosis factor alpha (TNF-?) and interleukin-1 (IL-1 )) and the stabilization of the messenger RNA. (MRNA) (e.g., interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem sites NF-KB (nuclear factor-kappa B). The sustained expression of VCAM-1 lasts more than 24 hours.
Mainly, the VCAM-1 protein is an endothelial ligand of the VLA-4 (Very Late Antigen-4 or ?4?1 integrin) of the ?1 integrin subfamily. VCAM-1 expression has also been observed in other cell types (eg, smooth muscle cells). It has also been shown to interact with EZR and Moesin.
CD106 also exists on the surface of certain sub-populations of mesenchymal stem cells (MSCs).
