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CD63
CD63
- 中文名称：
- CD63
- 英文名称：
- CD63
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59248
- 规格：
- 5 Slides|0.1 mL (Concentrate)|3 mL (RTU)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2 to 8 degree C in the dark.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1/K
克隆号:[NKI/C3]
特异性:N/A
纯度:N/A
形式：CD63 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
The protein encoded by CD63 gene is a member of the transmembrane-4 superfamily, also known as the tet-raspanin family, and mediates signal-transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell-surface glycoprotein that is known to complex with integrins. It may function as a blood-platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak Syndrome. This gene has been associated with tumor progression. CD63 is a good marker for flow-cytometric quantification of in vitro-activated basophils for identification of IgE-mediated allergy. The test is commonly designated as a basophil activation test. Anti-CD63 reacts with a 53 kDa protein. The antigen was originally designated as a lysosomal membrane protein characterized as an activation-dependent platelet surface antigen. In fact, the CD63 antigen has a diverse distribution on the surface and in the cytoplasm of many cell types including lymphoid, myeloid and endothelial cells and Melanoma. It is weakly expressed in granulocytes, B and T-cells. It has been quite useful in identifying Malignant Melanoma. CD63 is thought to be associated with the early stages of Melanoma tumor progression (in regulation of motility and adhesion of Melanoma cells).
