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p57
p57
- 中文名称：
- p57
- 英文名称：
- p57
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59251
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2 to 8 degree C in the dark.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2b/K
克隆号:[Kp10]
特异性:N/A
纯度:N/A
形式：p57 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
p57 or p57KIP2 is a tumor-suppressor human gene that belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. Thus, p57 causes arrest of the cell-cycle in G1 phase. A mutation of this gene may lead to loss of control over the cell-cycle leading to uncontrolled cellular proliferation. The gene encoding human p57KIP2 is located on chromosome 11p15.5, a region implicated in sporadic cancers, Wilm's Tumor and Beckwith Wiedemann Syndrome (BWS is characterized by increased risk of tumor formation in childhood), making it a tumor suppressor candidate. Anti-p57 has been used to aide in discriminating Complete Hydatidiform Mole (CHM) (no nuclear labeling of cytotrophoblasts) from Partial Hydatidiform Mole (PHM) and hydropic abortion. In normal placenta, many cytotrophoblast nuclei and stromal cells are labelled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous Trophoblastic Islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
