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CD42b, RMab (EP409)
CD42b, RMab (EP409)
- 中文名称：
- CD42b, RMab (EP409)
- 英文名称：
- CD42b, RMab (EP409)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59337
- 规格：
- 5 Slides|2x5 Slides|3x5 Slides|4x5 Slides|
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[EP409]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
CD42b is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
CD42b Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide is a protein that in humans is encoded by the GP1BA gene. The Gp Ib functions as a receptor for von Willebrand factor (VWF), which includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease (1).
CD42b antibody is a marker of megakaryocytes and platelets and used in the identification of AML-M7 to distinguish AML-M7 (CD42b+) from acute myelosis with myelofibrosis (usually CD42b -). Acute megakaryoblastic leukemia has a significantly higher proportion of blasts expressing CD42b (2). Patients with Histoplasma capsulatum infections have been noted with unusual IHC positivity of the platelet associated marker CD42b/GP1b expressed on the surface of this fungal organisms. Evaluation of additional cases demonstrated that a majority of histoplasmosis cases (83%) showed positive staining with CD42b/GP1b, comparable to GMS stain results (3).
