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Nanog (EP225)
Nanog (EP225)
- 中文名称：
- Nanog (EP225)
- 英文名称：
- Nanog (EP225)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59341
- 规格：
- 5 Slides|2x5 Slides|3x5 Slides|4x5 Slides|
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[EP225]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Nanog is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Homeobox protein Nanog is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. In humans, this protein is encoded by the NANOG gene. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Nanog is highly expressed in cancer stem cells and thus may function as an oncogene to promote carcinogenesis. High expression of Nanog correlates with poor survival in cancer patients.
Nanog antibody is highly and specifically expressed in carcinoma in situ (CIS), embryonal carcinomas, and seminomas, but not in teratomas and yolk sac tumors. Additionally, it has been reported that Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Positive Nanog expression is significantly associated with high-grade ovarian serous carcinoma and is absent in benign, borderline, and low-grade serous lesions. A study suggests the expression of Nanog exhibiting cellular shuttling behavior and increasing stromal distribution during the progression of cervical cancer. Recently it was suggested that Nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased overall survival (OS) and disease-free survival (DFS) for lung cancer.
