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Aurora B (RM278)
Aurora B (RM278)
- 中文名称：
- Aurora B (RM278)
- 英文名称：
- Aurora B (RM278)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59356
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RM278]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Anti-Aurora B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Aurora B kinase, a 39.3 kDa sized serine-threonine kinase, is a member of the Aurora family of mitotic kinases. The enzymatic activity of Aurora B kinase prevents stable kinetochore-microtubule attachments in early mitosis and promotes stabilization of the attachments in later mitosis due to low activity. The gene for Aurora B kinase (AURKB) is located on chromosome 17p13.1.
Abnormal expression of Aurora B antibody has been found in many cancer types, such as Non-Small Cell Lung Carcinoma, Mesothelioma, Glioblastoma, Oral Cancer and Hepatocellular Carcinoma. In Prostate and Colorectal Cancer, Aurora B expression directly correlates with the progression of cancer. In a study investigating the expression of Aurora B kinase in Thyroid Carcinoma, abundant expression of Aurora B kinase was detected in Anaplastic Carcinomas via IHC. A higher expression of Aurora B kinase in Anaplastic Thyroid Cancer than in differentiated Thyroid Cancer therefore suggests its use as a prognostic marker. In another immunohistochemical analysis, Aurora B antibody showed nuclear overexpression in high Gleason-grade Prostate Cancer, compared to low and intermediate grade cases. Additionally, there are numerous studies that indicate the use of Aurora B kinase as a prognostic marker in Ovarian Cancer. A study found that Aurora-B expression was correlated with the proliferation index (P < 0.001) and p53 expression (P = 0.014) in Breast cancer tissues and its expression was associated with lymph node metastasis (P = 0.002) and histological grade (P = 0.001). In conclusion, elevated Aurora-B expression in Breast Cancer patients contributes to chemoresistance and predicts poor prognosis.
