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Caspase-3 (RM250)
Caspase-3 (RM250)
- 中文名称：
- Caspase-3 (RM250)
- 英文名称：
- Caspase-3 (RM250)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59359
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RM250]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Casepase-3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Caspase-3 is a cysteine-aspartic acid protease encoded by the gene CASP3 on chromosome 4q35.1. Caspase-3 belongs to the caspase family, which is a family of enzymes crucial to mediating apoptosis. Once activated, Caspase-3 degrades intracellular proteins as well as functional proteins and induces cell death.
Dysregulated apoptosis is a typical characteristic of human cancer. Abnormal Caspase-3 antibody expression has been directly associated with acute Myelogenous Leukemia, where Caspase-3 overexpression has been detected. On the contrary, decreased expression of Caspase-3 has been found in Prostate Cancer. Another study has found a significant association between high Caspase-3 levels and increased death rates in Breast Cancer using IHC, highlighting the prognostic potential of Caspase-3. In another study, IHC analysis of Gastric, Ovarian, Cervical, and Colorectal Cancer demonstrated that patients with high expression of cleaved Caspase-3 had a significantly shorter overall survival time compared with those with low cleaved Caspase-3 expression. Additionally, a link between Caspase-3 antibody expression and tumor stage and lymph node metastasis was found in Gastric and Ovarian cancer. Caspase-3 is the predominant caspase involved in amyloid-beta precursor protein (APP) cleavage, consistent with its marked elevation in dying neurons of Alzheimer's disease brains and colocalization of its APP cleavage product with Abeta in senile plaques. Caspases thus appear to play a dual role in proteolytic processing of APP and the resulting propensity for Abeta peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease.
