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CD137/TNFRSF9 (BSB-159)
CD137/TNFRSF9 (BSB-159)
- 中文名称：
- CD137/TNFRSF9 (BSB-159)
- 英文名称：
- CD137/TNFRSF9 (BSB-159)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59361
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgM
克隆号:[BSB-159]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
CD137/TNFRSF9 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
CD137, or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as 4-1BB, is encoded by the TNFRSF9 gene on chromosome 1p36.23. CD137/TNFRSF9 is expressed on the surface of certain immune cells, such as Follicular Dendritic Cells, Monocytes, Mast Cells and Granulocytes. CD137/TNFRSF9 is barely detected on resting T cells or T-cell lines, and expression of CD137 is therefore activation dependent. It is found on activated CD4+, CD8+ or Natural Killer Cells. Activation of CD137 by its ligand, CD137L, upregulates survival genes, enhances cell division, induces cytokine production, and prevents activation-induced cell death in T cells.
One study demonstrated CD137 antibody positive IHC staining in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a test biomarker for CHL. CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells. Another study investigated CD137/TNFRSF9 via IHC in malignant tumor cells and found that there was an enhanced expression of CD137/TNFRSF9 in blood vessel cells of malignant tumors compared to blood vessel cells in benign tumors or inflammatory tissues. Further studies indicate the value of CD137 antibody as a prognostic marker in Diffuse Large B-cell Lymphomas, tumor cell differentiation in Gastric Cancer as well as the correlation between CD137/TNFRSF9 expression and bone metastasis of Breast Cancer. CD137/TNFRSF9 is considerably up-regulated in human Gliomas when compared with normal brain tissue. In addition, data provides evidence for an immune cell-independent de novo expression pattern of CD137/TNFRSF9 in mainly non-neoplastic reactive astrocytes and excludes classic immunological cell types, namely lymphocytes and microglia as the source of CD37/TNFRSF9. Moreover, TNFRSF9 is predominantly expressed in a perivascular and peritumoural distribution with significantly higher expression in IDH-1 mutant gliomas.
