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Claudin-7 (EP399)
Claudin-7 (EP399)
- 中文名称：
- Claudin-7 (EP399)
- 英文名称：
- Claudin-7 (EP399)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59363
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[EP399]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Claudin-7 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Claudin-7 is encoded by the CLDN7 gene and is a member of the claudin family. Claudin-7 is a component of tight junctions and plays important roles in maintaining cell polarity and tightly connecting the barriers between cells. Abnormal Claudin-7 protein expression is closely related to tumor occurrence, development, and metastasis. Claudin-7 expression is down-regulated in Colorectal Cancer (CRC) and Lung Cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis.
Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.
