-
CXCR5/CD185 (Polyclonal)
CXCR5/CD185 (Polyclonal)
- 中文名称：
- CXCR5/CD185 (Polyclonal)
- 英文名称：
- CXCR5/CD185 (Polyclonal)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59365
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
CXCR5 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
The G-protein coupled receptor (GPCR) or C-X-C motif chemokine receptor 5, CXCR5, also known as or Burkitt lymphoma receptor 1 (BLR1), plays fundamental roles in inflammatory, infectious and immune responses. Current evidence also indicates that the CXCL13:CXCR5 axis orchestrates cell-cell interactions that regulate lymphocyte infiltration within the tumor microenvironment, thereby determining responsiveness to cytotoxic and immune-targeted therapies. CXCR5 is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
CXCR5 antibody is highly expressed in primary and secondary follicles within gastric lymphomas. non-small cell lung cancer (NSCLC) tissues express CXCR5, which correlates with stage/grade of the disease. Higher CXCR5 expression and migration by NSCLC cells suggest a role in migration and metastasis of primary lung tumors in response to CXCL13. These findings indicate that differential expression patterns of CXCR5 and CXCL13 in two subtypes (squamous cell carcinoma and adenocarcinoma) of NSCLC are associated with differences in their prognosis and survival. It has been proposed that CXCR5/CXCL13, either alone or in combination, could be used as a prognostic biomarker for lung cancer. Other studies have shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases, and elevated CXCR5 antibody expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein. Another study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5 and found a correlation between the level of CXCR5 and Gleason score. CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers.
