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GAB1/GRB2-associated-binding protein 1 (BSB-155)
GAB1/GRB2-associated-binding protein 1 (BSB-155)
- 中文名称：
- GAB1/GRB2-associated-binding protein 1 (BSB-155)
- 英文名称：
- GAB1/GRB2-associated-binding protein 1 (BSB-155)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59371
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[BSB-155]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
GAB1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
GRB2-associated-binding protein 1 (GAB1) is encoded by the GAB1 gene. GAB1 is a member of the IRS1-like multisubstrate docking protein family that transduces signals from various tyrosine kinases, such as Met, FGFR1, and EGFR. GAB1 plays a central role in cellular growth response, transformation, and apoptosis, as well as inflammatory responses. GAB1 is involved in the amplification of IL-6- induced MAPK pathway and promotes inflammation.
Somatic mutations of the GAB1 gene have been detected in Breast and Colorectal Cancers and studies have shown that elevated expressions of GAB1 antibody have been associated with Breast Cancer metastasis by dissociating the polarity-associated partitioning defective (PAR) complex and promoting epithelial-to-mesenchymal transition. Upregulation of GAB1 is an indication of unfavorable prognosis for Hepatocellular Carcinoma and Epithelial Ovarian Cancer. GAB1 overexpression has also been seen in Adult Acute Lymphoblastic Leukemia and Medulloblastomas. GAB1 antibody can be used with a panel of immunohistochemical markers in the classification of Medulloblastomas into SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT subgroups.
