-
HSP70 (RM432)
HSP70 (RM432)
- 中文名称：
- HSP70 (RM432)
- 英文名称：
- HSP70 (RM432)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59374
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RM432]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
HSP70 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
70 kDa heat shock proteins (HSP70) are found ubiquitously in virtually all living organisms, facilitating protein folding and protecting cells from heat stress and toxic chemicals. HSP70 proteins have 3 functional domains: N-terminal ATPase domain, substrate binding domain, and a C-terminal domain that serves as a "lid" for the substrate binding domain. HSP70 binds tightly to partially synthesized peptides and prevents them from aggregating and rendering nonfunctional. HSP70 also inhibits apoptosis by blocking the recruitment of procaspase-9 to the Apaf-1/dATP/cytochrome c apoptosome complex.
HSP70 antibody is shown to be overexpressed in malignant Melanoma and underexpressed in Renal Cell Carcinoma. A variety of tumor cells can express HSP70 with seemingly contradictory functions. Intracellular HSP70 has a cytoprotective function via suppression of apoptosis and lysosomal cell death (LCD) and extracellular HSP70 can promote tumorigenesis and angiogenesis. Other evidence showed intracellular HSP70 can promote apoptosis and membrane-associated/extracellular HSP70 can elicit antitumor innate and adaptive immune responses.
One study evaluated the expression of HSP70 antibody, Estrogen Receptor (ER) and Ki-67 and assessed the relationship between them in Cervical Squamous Cell Neoplasia. It found that HSP70 may play an important role in tumor cell proliferation and is more related with invasive Squamous Cell Carcinoma than Cervical Intraepithelial Neoplasia, but ER may be not related with tumor cell proliferation and differentiation. Therefore, HSP70 may be a useful prognostic factor in Cervical Dysplasia and Cancer.
