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Laminin-R/RPSA (BSB-144)
Laminin-R/RPSA (BSB-144)
- 中文名称：
- Laminin-R/RPSA (BSB-144)
- 英文名称：
- Laminin-R/RPSA (BSB-144)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59380
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-144]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Lamin-R is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Laminin receptor (Ribosomal Protein SA or 67LR) is a 67kDa protein in the extracellular matrix, coded by a 5,833 bp gene on Chromosome 3,containing seven exons and six introns. Laminin-R is involved in cellular adhesion to basement membranes and signal transduction pathways after binding the ligand Integrin-1. The receptor is also involved in pathways of cytoskeletal movement, chromatin structure, cellular migration, stress response, ribosomal function, translation, and rRNA processing. Laminin-R is also a receptor for green tea polyphenol and mediator in the Nitrous Oxide (eNOS) pathways used to force cancer cells into apoptosis. The 37kDa precursor protein, known also as p40, is a highly-conserved protein in the 40S ribosomal subunit.
Laminin-R antibody has been found to be overexpressed in Breast, Colorectal, Pancreatic, Prostate, and Cervical Cancer, and in Lymphomas. Laminin-R interacts with cyclin-dependent kinases and inhibitors to control G1/S, S/G2 and G2/M phase cell cycle arrest; down-regulation of the receptor is correlated with arrested cell growth and a reduction in the development of tumors. Laminin-R has also been found to be involved in regulation of Survivin expression, as well as cancer metastasis and drug resistance
