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Thymidylate synthase/TS (BSB-160)
Thymidylate synthase/TS (BSB-160)
- 中文名称：
- Thymidylate synthase/TS (BSB-160)
- 英文名称：
- Thymidylate synthase/TS (BSB-160)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59393
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[BSB-160]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Thymidylate Synthase is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate to deoxythymidine monophosphate using 5, 10-methylenetetrahydrofolate as a cofactor. This enzyme is critical for DNA repair and replication. Polymorphism of the gene TYMS, which encodes TS, may be associated with etiology of neoplasia and responses to chemotherapy. TS inhibitors like 5-fluorouracil have been successful in down-regulating tumor progression and increasing immune responses in pancreatic, breast, gastric, ovarian, lung, and head & neck cancer.
A study reported Thymidylate synthase antibody expression and gene copy number (GCN) were assayed using IHC and silver in situ hybridization (SISH), respectively, on primary tumors of resected non-small cell lung (NSCLC) patients and concluded that TS PE and GCN vary widely in NSCLC and correlate significantly to each other. TS GCN is higher in SCCs, whereas TS PE does not associate with histological subtypes, clinical features or survival. Variability of Thymidylate synthase antibody expression and GCN may indicate potential benefit from pemetrexed therapy in selected SCC patients. A number of studies have investigated the relationship between thymidylate synthase (TS) expression and survival in colorectal cancer (CRC) patients. Most have reported poorer overall and progression-free survival with high Thymidylate synthase antibody expression. Another study suggests that immunostaining for TS and p53 protein is useful for pretreatment selection of gastric cancer patients unresponsive to S-1/cisplatin chemotherapy.
