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Trop-2/EGP-1 (BSB-148)
Trop-2/EGP-1 (BSB-148)
- 中文名称：
- Trop-2/EGP-1 (BSB-148)
- 英文名称：
- Trop-2/EGP-1 (BSB-148)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59396
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-148]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Anti-Trop-2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Trop-2 or Tumor-associated calcium signal transducer 2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This transmembrane glycoprotein functions in a variety of cell signaling pathways and was first elucidated as a transducer of an intracellular calcium signal. Trop-2 expression has been demonstrated to depend on a large variety of transcription factors. Trop-2 is involved in several cell signaling pathways, of which many are associated with tumorigenesis.
In Thyroid Cancer cell invasion, Trop-2 signal transduction has been seen as a downstream effect of the ERK and JNK pathways, where its signaling enhances stem cell-like properties of cancer cells, as Trop-2 regulates proliferation and self-renewal through-catenin signaling. In a study, the majority of Papillary Thyroid Carcinoma (PTC) specimens were positive for Trop-2; however, the pattern of staining differed significantly between the histopathological variants. All Papillary microcarcinomas (mPTC), PTC classic variant (PTC cv), and tall cell variants (PTC tcv) were Trop-2 positive, with mainly diffuse staining. In contrast, less than half of the PTC follicular variant specimens were positive for Trop-2, with only focal immunoreactivity. Trop-2 may play a role in tumor progression given the involvement in several molecular pathways traditionally associated with cancer development. High Trop-2 antibody expression correlates with poor prognosis in Pancreatic Carcinoma, Hilar Cholangiocarcinoma, Cervical Cancer, Gastric Cancer, and others. Increased Trop-2 antibody expression has been associated with poor overall and disease-free survival outcomes across several solid tumors. Given Trop-2's expression pattern and associated poor prognostic outcomes, Trop-2 is a rational prognostic marker and a possible therapeutic target.
